Phenotypes Associated with This Genotype

Genotype
MGI:3776626

• Allelic Composition: S100a10^tm1Pggd/S100a10^tm1Pggd
• Genetic Background: involves: 129S/SvEv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired behavioral response to xenobiotic ( J:104116 , J:131963 )

• mice treated with anpirtoline fail to exhibit decrease thigmotaxis as do wild-type mice (J:104116)

• mice fail to exhibit rotational motion when treated with CP94253, a 5-HT1BR agonist, unlike wild-type mice (J:131963)

abnormal depression-related behavior ( J:104116 )

• mice exhibit increased depression-related behavior such as immobility when suspended by their tails

• mice consume less of a palatable 2% sucrose solution compared to wild-type mice without abnormal water consumption

increased thigmotaxis ( J:104116 )

• mice exhibit increased thigmotaxis compared to wild-type mice

homeostasis/metabolism

abnormal serotonin level ( J:104116 )

• mice exhibit increased levels of serotonin turnover and/or metabolism compared to wild-type mice

abnormal response/metabolism to endogenous compounds ( J:104116 )

• application of serotonin in the perfusion solution around brain slices fails to depress field excitatory postsynaptic potential unlike in wild-type mice