Phenotypes Associated with This Genotype

Genotype
MGI:3776499

• Allelic Composition: Pkd1^tm1Bdgz/Pkd1^tm1Bdgz
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:130086 )

• no homozygous animals are identified at weaning

renal/urinary system

kidney cyst ( J:130086 )

• develop by E16.5

• E13.5 kidneys grown in vitro for 5 days with 8-Br-cAMP in the culture media display cyst formation, with higher cystic percentage than heterozygous or wild-type kidneys

• in culture, treatment with R-roscovitine inhibits cystogenesis significantly

endocrine/exocrine glands

pancreas cyst ( J:130086 )

• develop by E15.5

homeostasis/metabolism

skin edema ( J:130086 )

• embryos display edema by E13.5, becoming severe by E16.5

integument

skin edema ( J:130086 )

• embryos display edema by E13.5, becoming severe by E16.5

growth/size/body

pancreas cyst ( J:130086 )

• develop by E15.5

kidney cyst ( J:130086 )

• develop by E16.5

• E13.5 kidneys grown in vitro for 5 days with 8-Br-cAMP in the culture media display cyst formation, with higher cystic percentage than heterozygous or wild-type kidneys

• in culture, treatment with R-roscovitine inhibits cystogenesis significantly