Phenotypes Associated with This Genotype

Genotype
MGI:3776491

• Allelic Composition: Tlr9^m4Btlr/Tlr9⁺
• Genetic Background: C57BL/6J-Tlr9^m4Btlr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased B cell proliferation ( J:132489 )

• naive peripheral B lymphocytes from heterozygous mutant mice fail to proliferate in vitro in response to stimulation with CPG ODN

abnormal macrophage physiology ( J:132489 )

• peritoneal macrophages from mice heterozygous for this mutation secrete little or no tumor necrosis factor- (TNF-) alpha in response to oligonucleotides containing unmethylated CpG motifs (CPG ODNs)

• responses of heterozygous mutant peritoneal macrophages to all TLR ligands except CPG ODNs are similar to those of wild-type macrophages

abnormal plasmacytoid dendritic cell physiology ( J:132489 )

• plasmacytoid dendritic cells (pDCs) from heterozygous mutant mice do not produce interferon alpha in response to mouse cytomegalovirus (MCMV), herpes simplex virus type I (HSV-1) or herpes simplex virus type 2 (HSV-2)

hematopoietic system

decreased B cell proliferation ( J:132489 )

• naive peripheral B lymphocytes from heterozygous mutant mice fail to proliferate in vitro in response to stimulation with CPG ODN

abnormal macrophage physiology ( J:132489 )

• peritoneal macrophages from mice heterozygous for this mutation secrete little or no tumor necrosis factor- (TNF-) alpha in response to oligonucleotides containing unmethylated CpG motifs (CPG ODNs)

• responses of heterozygous mutant peritoneal macrophages to all TLR ligands except CPG ODNs are similar to those of wild-type macrophages

cellular

decreased B cell proliferation ( J:132489 )

• naive peripheral B lymphocytes from heterozygous mutant mice fail to proliferate in vitro in response to stimulation with CPG ODN