Phenotypes Associated with This Genotype

Genotype
MGI:3776435

• Allelic Composition: Dll1^tm1Gos/Dll1^tm2Gos; Jag2^tm1Grid/Jag2^tm1Grid
• Genetic Background: involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hearing/vestibular/ear

abnormal organ of Corti morphology ( J:132241 )

• unlike in wild-type mice, cells within the organ of Corti continue to proliferate between E14.5 and E17.5

abnormal cochlear hair cell morphology ( J:132241 )

• hair cells are disorganized and very densely packed

increased cochlear inner hair cell number ( J:132241 )

• cochlea exhibit a greater increase in inner hair cells than in Jag2^tm1Grid homozygotes

increased cochlear outer hair cell number ( J:132241 )

abnormal orientation of cochlear hair cell stereociliary bundles ( J:132241 )

• hair cell stereocilia bundles exhibit a lose of polarity and disorganization

decreased organ of Corti supporting cell number ( J:132241 )

• many of the missing supporting cells are derived from the Deiter's cell population

nervous system

abnormal cochlear hair cell morphology ( J:132241 )

• hair cells are disorganized and very densely packed

increased cochlear inner hair cell number ( J:132241 )

• cochlea exhibit a greater increase in inner hair cells than in Jag2^tm1Grid homozygotes

increased cochlear outer hair cell number ( J:132241 )

abnormal orientation of cochlear hair cell stereociliary bundles ( J:132241 )

• hair cell stereocilia bundles exhibit a lose of polarity and disorganization