Phenotypes Associated with This Genotype

Genotype
MGI:3776428

• Allelic Composition: Dll1^tm1Gos/Dll1^tm2Gos
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:119082 )

• mice survive until birth

• mice do not survive postnatally

• however, mice survive beyond E10.5 when Dll1^tm1Gos homozygotes die

cellular

abnormal myoblast differentiation ( J:119082 )

• progenitor cells are lost due to premature differentiation and not an increase in apoptosis

• dermomyotome-derived myoblasts differentiate more rapidly than in wild-type mice

abnormal myotube differentiation ( J:119082 )

• beginning at E14.5, the number of secondary myotubes are severely reduced

muscle

abnormal myoblast differentiation ( J:119082 )

• progenitor cells are lost due to premature differentiation and not an increase in apoptosis

• dermomyotome-derived myoblasts differentiate more rapidly than in wild-type mice

abnormal myotube differentiation ( J:119082 )

• beginning at E14.5, the number of secondary myotubes are severely reduced

decreased skeletal muscle mass ( J:119082 )

• at E13.5, skeletal muscle is hypotrophied

• at E18.5, skeletal muscle is severely reduced

behavior/neurological

no spontaneous movement ( J:119082 )

• mice are motionless at E18.5

embryo

abnormal somite development ( J:132241 )

• mice exhibit defects in segmentation due to disrupted somitogenesis

skeleton

abnormal axial skeleton morphology ( J:119082 )

growth/size/body

decreased body length ( J:119082 )