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Phenotypes Associated with This Genotype
Genotype
MGI:3776092
Allelic
Composition
Agrptm2(HBEGF)Rpa/Agrp+
Tg(Pomc-EGFP)1Low/0
Genetic
Background
involves: 129S4/SvJaeSor * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Agrptm2(HBEGF)Rpa mutation (1 available); any Agrp mutation (17 available)
Tg(Pomc-EGFP)1Low mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• adult mice treated with diptheria toxin (DT) to specifically ablate NPY-expressing cells exhibit 20% of their body weight unlike similarly treated wild-type mice

nervous system
• mice treated with diptheria toxin (DT) to specifically ablate NPY-expressing cells exhibit miniature inhibitory postsynaptic currents that are 6-fold lower than in wild-type mice and lower than in fasted wild-type mice


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory