Phenotypes Associated with This Genotype

Genotype
MGI:3776082

• Allelic Composition: Agrp^{tm2(HBEGF)Rpa}/Agrp^{tm2(HBEGF)Rpa}
• Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

abnormal induced morbidity/mortality ( J:132360 )

• adult mice injected intramuscularly with diptheria toxin (DT) to specifically ablate NPY-expressing cells exhibit a greater than 80% drop in feeding, a 20% reduction in their body weight and have to be euthanized unlike similarly treated wild-type mice

• however, most mice survive when injected with DT as neonate or when receiving injections as neonate and adults

behavior/neurological

hyperdipsia ( J:132360 )

• adult mice injected intramuscularly with diptheria toxin (DT) to specifically ablate NPY-expressing cells exhibit increased water consumption compared to similarly treated wild-type mice

abnormal eating behavior ( J:132360 )

• adult mice injected intramuscularly with diptheria toxin (DT) to specifically ablate NPY-expressing cells exhibit a greater than 80% drop in feeding unlike similarly treated wild-type mice

• adults injected with DT cease to eat unlike similarly treated wild-type mice

• however, DT-treated mice are sustained by hand feeding via oral gavage with liquid food

growth/size/body

decreased body weight ( J:132360 )

• adult mice injected intramuscularly with diptheria toxin (DT) to specifically ablate NPY-expressing cells exhibit 20% of their body weight unlike similarly treated wild-type mice