Phenotypes Associated with This Genotype

Genotype
MGI:3775457

• Allelic Composition: Apcs^tm1Mpe/Apcs^tm1Mpe
• Genetic Background: 129.Cg-Apcs^tm1Mpe

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased susceptibility to bacterial infection induced morbidity/mortality ( J:125473 )

• mice exhibit decreased mortality when infected with S. pyogenes

increased susceptibility to bacterial infection induced morbidity/mortality ( J:125473 )

• mice exhibit increased mortality when infected with E. coli compared to wild-type mice

immune system

immune system phenotype ( J:90502 )

N • Background Sensitivity: unlike mice on a C56BL/6 background, mice on a 129 background do not develop increased autoimmune antibodies spontaneously or following induction by active immunization

glomerulonephritis ( J:90502 )

• infrequent and moderate

decreased susceptibility to bacterial infection induced morbidity/mortality ( J:125473 )

• mice exhibit decreased mortality when infected with S. pyogenes

increased susceptibility to bacterial infection induced morbidity/mortality ( J:125473 )

• mice exhibit increased mortality when infected with E. coli compared to wild-type mice

renal/urinary system

glomerulonephritis ( J:90502 )

• infrequent and moderate