Phenotypes Associated with This Genotype

Genotype
MGI:3775301

• Allelic Composition: Igf1r^tm1.2Mhz/Igf1r^tm1.2Mhz
• Genetic Background: involves: 129/Sv * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:63460 )

• at birth mice cannot breath and die within the first few minutes of life

respiratory system

respiratory failure ( J:63460 )

• at birth mice cannot breath

growth/size/body

decreased body weight ( J:63460 )

• mice are 50.3% of wild-type weight

muscle

abnormal muscle morphology ( J:63460 )

• mice exhibit general hypotrophia with particularly underdeveloped intercostals muscles