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Phenotypes Associated with This Genotype
Genotype
MGI:3775271
Allelic
Composition		 Hrh4tm1Lex/Hrh4+
Genetic
Background		 involves: 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hrh4tm1Lex mutation (1 available); any Hrh4 mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal mast cell physiology ( J:132140 )
• mast cells do not respond to 30 uM histamine stimulation by mobilizing calcium as strongly as wild-type cells

hematopoietic system
abnormal mast cell physiology ( J:132140 )
• mast cells do not respond to 30 uM histamine stimulation by mobilizing calcium as strongly as wild-type cells

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory