Phenotypes Associated with This Genotype

Genotype
MGI:3774860

• Allelic Composition: Stk11^tm1.2Rdp/Stk11⁺
• Genetic Background: involves: 129S6/SvEvTac * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased endometrial carcinoma incidence ( J:131865 )

♀ • 53% of female mice that survive to 55 weeks of age have endometrial adenocarcinomas that developed spontaneously

♀ • tumors consisted of endometrial-type glands invading into the myometrium

♀ • tumors maintained polarity of cells found in normal endometrial glands

digestive/alimentary system

intestine polyps ( J:131865 )

• 40 of 59 mice develop gastrointestinal polyps by 43 weeks of age

reproductive system

increased endometrial carcinoma incidence ( J:131865 )

♀ • 53% of female mice that survive to 55 weeks of age have endometrial adenocarcinomas that developed spontaneously

♀ • tumors consisted of endometrial-type glands invading into the myometrium

♀ • tumors maintained polarity of cells found in normal endometrial glands