Analysis Tools
mortality/aging
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• mice die prematurely between 25 and 65 days of age
• Background Sensitivity: double mutants on mixed background (3 or less backcrosses to C57BL/6) show increased lifespan generally reaching 6 months of age and remaining healthy until 2 months of age, compared to accelerated phenotype of congenic mutants
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growth/size/body
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• double null mice are significantly underweight (60% of weight of wild-type mice)
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hematopoietic system
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• pre B cell numbers are similar in double null and wild-type mice, but few B cells develop further to CD19+ CD43- B cells
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• immature IgM+ IgD- B cells are decreased in number in the bone marrow
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• there is a higher proportion of transitional stage B cells, but absolute B cell number is decreased
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• spleens contain a cell population expressing CD19 but not IgM of IgD; cells are slightly bigger than normal B cells
• Background Sensitivity: myeloproliferative disorder with extramedullary hematopoiesis develops in congenic mice earlier than mice on mixed background
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• prior to death, mice develop a myeloproliferative disorder and show extramedullary hematopoiesis
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• B cell lymphopenia develops; total cell numbers in spleens and lymph nodes are substatiantially lower than in wild-type mice or either single mutant homozygotes
• marked decreases in B cell numbers and percentages are observed in the bone marrow relative to controls
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• practically no recirculating mature IgM+ IgD+ B cells are detected in the bone marrow
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• in double mutants on mixed background, follicular lymph node B cells express higher amounts of IgM than wild-type or Ptprjtm1.2Weis cells
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• mice develop myeloproliferative disorder and show distortion of splenic architecture
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immune system
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• pre B cell numbers are similar in double null and wild-type mice, but few B cells develop further to CD19+ CD43- B cells
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• immature IgM+ IgD- B cells are decreased in number in the bone marrow
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• there is a higher proportion of transitional stage B cells, but absolute B cell number is decreased
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• spleens contain a cell population expressing CD19 but not IgM of IgD; cells are slightly bigger than normal B cells
• Background Sensitivity: myeloproliferative disorder with extramedullary hematopoiesis develops in congenic mice earlier than mice on mixed background
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• B cell lymphopenia develops; total cell numbers in spleens and lymph nodes are substatiantially lower than in wild-type mice or either single mutant homozygotes
• marked decreases in B cell numbers and percentages are observed in the bone marrow relative to controls
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• practically no recirculating mature IgM+ IgD+ B cells are detected in the bone marrow
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• in double mutants on mixed background, follicular lymph node B cells express higher amounts of IgM than wild-type or Ptprjtm1.2Weis cells
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• mice develop myeloproliferative disorder and show distortion of splenic architecture
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• extensive myeloid infiltration of liver is observed
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• scattered myeloid infiltrates are detected in the lungs
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liver/biliary system
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• extensive myeloid infiltration of liver is observed
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respiratory system
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• scattered myeloid infiltrates are detected in the lungs
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