Phenotypes Associated with This Genotype

Genotype
MGI:3774856

• Allelic Composition: Ptprc^tm1Mak/Ptprc^tm1Mak; Ptprj^tm1.2Weis/Ptprj^tm1.2Weis
• Genetic Background: involves: 129/Sv * 129P2/OlaHsd * BALB/cJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:131736 )

• Background Sensitivity: on mixed background, mice live until 6 months and remain healthy until 2 months of age, compared to mice on congenic background which display earlier lethality and accelerated B cell phenotype

hematopoietic system

impaired macrophage phagocytosis ( J:131736 )

• Fc receptor mediated phagocytosis by bone marrow-derived macrophages is decreased by 40% relative to wild-type

abnormal myelopoiesis ( J:131736 )

• Background Sensitivity: on mixed background, myeloproliferative disorder in mice is delayed in development compared to congenic mutants

decreased B cell number ( J:131736 )

• Background Sensitivity: young mice on mixed background show mild reduction in B cell number whereas reduction becomes more severe on congenic C57BL/6 background; B cell lymphopenia develops due to profound block at pre-B cell stage of development in the bone marrow

abnormal follicular B cell morphology ( J:131736 )

• in double mutants on mixed background, follicular lymph node B cells express higher amounts of IgM than wild-type or Ptprj^tm1.2Weis cells

abnormal B cell physiology ( J:131736 )

• B cells show delayed calcium ion flux after B cell receptor crosslinking compared to wild-type and single null mice at 6-8 weeks of age

immune system

impaired macrophage phagocytosis ( J:131736 )

• Fc receptor mediated phagocytosis by bone marrow-derived macrophages is decreased by 40% relative to wild-type

abnormal myelopoiesis ( J:131736 )

• Background Sensitivity: on mixed background, myeloproliferative disorder in mice is delayed in development compared to congenic mutants

decreased B cell number ( J:131736 )

• Background Sensitivity: young mice on mixed background show mild reduction in B cell number whereas reduction becomes more severe on congenic C57BL/6 background; B cell lymphopenia develops due to profound block at pre-B cell stage of development in the bone marrow

abnormal follicular B cell morphology ( J:131736 )

• in double mutants on mixed background, follicular lymph node B cells express higher amounts of IgM than wild-type or Ptprj^tm1.2Weis cells

abnormal B cell physiology ( J:131736 )

• B cells show delayed calcium ion flux after B cell receptor crosslinking compared to wild-type and single null mice at 6-8 weeks of age

abnormal cytokine secretion ( J:131736 )

• Fc receptor-induced tumor necrosis factor alpha production (Tnfa) by bone marrow-derived macrophages in double mutant mice

• after LPS treatment Tnfa production by macrophages is equivalent to wild-type cells

cellular

impaired macrophage phagocytosis ( J:131736 )

• Fc receptor mediated phagocytosis by bone marrow-derived macrophages is decreased by 40% relative to wild-type