Phenotypes Associated with This Genotype

Genotype
MGI:3774770

• Allelic Composition: Cdkn2a^tm1Cjs/Cdkn2a^tm1Cjs; Trp53^tm1Brd/Trp53^tm1Brd
• Genetic Background: involves: 129S7/SvEvBrd * 129X1/SvJ * C57BL/6 * NIH/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Tumor multiplicity and proliferation index in Cdkn2a^tm1Cjs/Cdkn2a^tm1Cjs, Trp53^tm1Brd/Trp53^tm1Brd and Cdkn2a^tm1Cjs/Cdkn2a^tm1Cjs Trp53^tm1Brd/Trp53^tm1Brd mice

neoplasm

increased tumor growth/size ( J:93298 )

• mutants show a papilloma multiplicity similar to wild-type after DMBA/TPA treatment, however tumors that develop are larger than in wild-type

abnormal tumor incidence ( J:93298 )

• tumor development is similar to wild-type after DMBA/TPA treatment although tumors are flatter and grow in an endophytic pattern compared to a highly exophytic pattern

• however, tumor progression is accelerated compared to single Trp53 homozygotes

increased carcinoma incidence ( J:93298 )

• carcinoma latency and multiplicity after DMBA/TPA is similar to that seen in single homozygous Cdkn2a mutants, however size of carcinomas is larger than in wild-type or in single Trp53 mutants