Phenotypes Associated with This Genotype

Genotype
MGI:3774768

• Allelic Composition: Cdkn2a^tm1Cjs/Cdkn2a⁺
• Genetic Background: involves: 129X1/SvJ * C57BL/6 * NIH/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased incidence of tumors by chemical induction ( J:93298 )

• by 20 weeks after a single dose of DMBA and twice weekly application of TPA for 15 weeks, mutants show an increase in papilloma number and size compared to wild-type

• tumors of heterozygous mice show loss of heterozygosity during benign to malignant conversion

increased carcinoma incidence ( J:93298 )

• by 28 weeks, 60% of DMBA/TPA treated heterozygotes develop carcinomas compared to 25% of wild-type

increased papilloma incidence ( J:93298 )

• mutants have an average of 2.6 more papillomas than wild-type after DMBA/TPA treatment

homeostasis/metabolism

increased incidence of tumors by chemical induction ( J:93298 )

• by 20 weeks after a single dose of DMBA and twice weekly application of TPA for 15 weeks, mutants show an increase in papilloma number and size compared to wild-type

• tumors of heterozygous mice show loss of heterozygosity during benign to malignant conversion