Mouse Genome Informatics
hm
    Sprtm1Lex/Sprtm1Lex
involves: 129S/SvEvBrd * C57BL/6J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• most mice die between 3 and 4 weeks of age with some mice surviving until week 13
• fewer than expected mice are born

homeostasis/metabolism
• liver phenylalanine levels are decreased compared to in wild-type mice
• dopamine, noradrenaline and a serotonin levels are decreased 20% compared to in wild-type mice
• dopamine, noradrenaline and a serotonin levels are decreased 20% compared to in wild-type mice
• biopterin levels are undetectable unlike in wild-type mice
• pterin levels are increased in the brain
• dihydrobiopterin levels are decreased in the liver
• neopterin levels are increased in the brain, liver and kidney compared to in wild-type mice
• dopamine, noradrenaline and a serotonin levels are decreased 20% compared to in wild-type mice

behavior/neurological
• after weaning mice exhibit tremor-like symptoms in their forelegs and bradykinesia
• young mice and post-weaning mice exhibit bradykinesia

growth/size/body
• mice weigh 30% less than wild-type

nervous system
• dopamine, noradrenaline and a serotonin levels are decreased 20% compared to in wild-type mice

Mouse Models of Human Disease
OMIM IDRef(s)
Parkinson Disease 3, Autosomal Dominant; PARK3 602404 J:131376