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Phenotypes Associated with This Genotype
Genotype
MGI:3774583
Allelic
Composition
Pdx1tm1Cvw/Pdx1tm4Cvw
Tg(Ins2-cre)25Mgn/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6 * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdx1tm1Cvw mutation (1 available); any Pdx1 mutation (15 available)
Pdx1tm4Cvw mutation (1 available); any Pdx1 mutation (15 available)
Tg(Ins2-cre)25Mgn mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• proliferation of Pdx1- cells is decreased compared to in wild-type pancreas
• beginning at E18.5, the number of glucagon+ cells is increased
• by one month of age mice are overtly diabetic with increased numbers of glucagon+ cells
• proliferation of glucagon+ cells is increased
• the proliferation of insulin+ cells is decreased
• the number of insulin+ cells decreases as the number of glucagon+ cells increases
• by one month of age mice are overtly diabetic with decreased insulin immunoreactivity in remaining insulin+ cells
• by one month of age mice are overtly diabetic with increased numbers of somatostatin+ cells
• glucagon+ and somatostatin+ cells are scattered throughout the islet instead of localized to the periphery as in wild-type mice

homeostasis/metabolism
• insulin levels following administration of glucose are lower in males and females compared to wild-type mice
• unlike male mice, females exhibit only mild glucose intolerance compared to wild-type females

Mouse Models of Human Disease
OMIM ID Ref(s)
Diabetes Mellitus, Insulin-Dependent; IDDM 222100 J:130389


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory