Phenotypes Associated with This Genotype

Genotype
MGI:3774493

• Allelic Composition: Kcna2^tm1Tem/Kcna2⁺
• Genetic Background: C3Fe.129S7-Kcna2^tm1Tem

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

increased susceptibility to pharmacologically induced seizures ( J:131735 )

• mice exhibit a shorter latency to seizure following treatment with flurothyl compared to wild-type mice but not as short as in homozygotes

impaired ability to fire action potentials ( J:131735 )

• neurons fire fewer action potentials than wild-type mice

• neurons hypoexcitability does not change depending on the age of mice

behavior/neurological

increased susceptibility to pharmacologically induced seizures ( J:131735 )

• mice exhibit a shorter latency to seizure following treatment with flurothyl compared to wild-type mice but not as short as in homozygotes