Phenotypes Associated with This Genotype

Genotype
MGI:3774492

• Allelic Composition: Kcna2^tm1Tem/Kcna2^tm1Tem
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:131735 )

• mice survive 17+/-2 days

• observed seizure fatality rate does not increased with age

nervous system

tonic seizures ( J:131735 )

• mice exhibit bursts of wild running and jumping followed by 5 to 10 seconds of full tonic extension similar to running bouncing seizures (RBS)

• observed seizure fatality rate does not increased with age

behavior/neurological

behavior/neurological phenotype ( J:131735 )

N • unlike mice homozygous for a null allele of Kcna1, mice do not exhibit hyperexcitability following a cold swim

tonic seizures ( J:131735 )

• mice exhibit bursts of wild running and jumping followed by 5 to 10 seconds of full tonic extension similar to running bouncing seizures (RBS)

• observed seizure fatality rate does not increased with age