Analysis Tools
reproductive system
 N |
• anogenital distances and internal urogenital organs, with exception of prostate gland, show no differences from wild-type
• no difference relative to wild-type in terms of fertility is observed
|
|
|
• at 9 weeks of age, some ventral prostate ducts lose glandular infoldings and have abnormal epithelial cells; enlarged ducts have many sloughed epithelial cells
• by 14 weeks, glandular infoldings have become smaller and shorter, some with constriction at their base, and layers of sloughed epithelial cells are observed in prostate lumen; by 32 weeks, mutant tissue lacks glandular infolding
• by week 24, layers of sloughed epithelium, immune cells and DNA fragments are observed in lumen of ducts in ventral prostate; many TUNEL-positive cells are detected in prostatic lumen at 24 weeks
|
|
|
• at 9 weeks of age, some ducts in the ventral prostate contain short or low cuboidal cells compared to taller or columnar epithelial cells in wild-type males; at 14 weeks, around 50% of ducts within the ventral prostate have altered epithelial architecture, with short poorly differentiated epithelial cells
• at 14-32 weeks, epithelial cells are shrunken
• by week 24, proliferation in the epithelium of all lobes except for anterior prostatic lobe is increased significantly compared to wild-type prostates
• epithelial cells appear to undergo anoikis and detach from the basement membrane
|
|
|
• at week 24, ventral prostates of mutants are substantially larger than in wild-type males
• however, dorsal-lateral prostates and anterior prostates show no changes in size
|
endocrine/exocrine glands
|
|
• at 9 weeks of age, some ventral prostate ducts lose glandular infoldings and have abnormal epithelial cells; enlarged ducts have many sloughed epithelial cells
• by 14 weeks, glandular infoldings have become smaller and shorter, some with constriction at their base, and layers of sloughed epithelial cells are observed in prostate lumen; by 32 weeks, mutant tissue lacks glandular infolding
• by week 24, layers of sloughed epithelium, immune cells and DNA fragments are observed in lumen of ducts in ventral prostate; many TUNEL-positive cells are detected in prostatic lumen at 24 weeks
|
|
|
• at 9 weeks of age, some ducts in the ventral prostate contain short or low cuboidal cells compared to taller or columnar epithelial cells in wild-type males; at 14 weeks, around 50% of ducts within the ventral prostate have altered epithelial architecture, with short poorly differentiated epithelial cells
• at 14-32 weeks, epithelial cells are shrunken
• by week 24, proliferation in the epithelium of all lobes except for anterior prostatic lobe is increased significantly compared to wild-type prostates
• epithelial cells appear to undergo anoikis and detach from the basement membrane
|
|
|
• at week 24, ventral prostates of mutants are substantially larger than in wild-type males
• however, dorsal-lateral prostates and anterior prostates show no changes in size
|
homeostasis/metabolism
|
N |
• serum testosterone levels at 12 and 24 weeks of age are similar to those in wild-type males
|
