Analysis Tools
adipose tissue
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• female mice have a 2-fold gain in mg of BAT compared to littermate controls
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• female mice have almost a 2-fold increase in fat pad weight compared to wild-type controls
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• female mice have about a 2-fold increase in fat pad weight compared to wild-type controls
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• female mice have about a 2-fold increase in fat pad weight compared to wild-type controls
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• female and male mice have a 1.6-fold gain in percentage of body fat compared to littermate controls
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behavior/neurological
| N |
• food consumption and circulating levels of leptin are close to wild-type levels, which is significantly less compared to mice with only the Ay mutant allele
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• locomotor activity is about 1.5-fold higher compared to wild-type control mice
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growth/size/body
| N |
• mean body weight and length of 20-23 week old mice is similar to wild-type littermate controls and is less than is observed in mice with only the Ay mutant allele
• weight and percentage of body fat in female mice is higher than in wild-type mice but is significantly lower than is observed in mice with only the Ay mutant allele
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• male but not female mice gain weight at a greater rate than littermate controls starting at six weeks of age
• rate of weight gain in male mice is significantly less than in Ay heterozygotes
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pigmentation
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• mice have a yellow coat color
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integument
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• mice have a yellow coat color
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