Phenotypes Associated with This Genotype

Genotype
MGI:3773280

• Allelic Composition: Cd28^tm1Mak/Cd28^tm1Mak; Tg(Cd4-cre)1Cwi/?; Traf6^tm2Ywc/Traf6^tm2Ywc
• Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased T cell proliferation ( J:130882 )

• CD4 T cells proliferate in vitro at normal levels when stimulated with anti-CD3 antibody compared

increased memory T cell number ( J:130882 )

• increased number of CD44^highCD62^low T cells in the spleen and lymph nodes

increased activated T cell number ( J:130882 )

• increased number of CD69⁺ T cells are found in the spleen and lymph nodes

decreased interleukin-2 secretion ( J:130882 )

• CD4 T cells secrete IL-2 upon stimulation with anti -CD3 or -CD3/-CD28 antibodies

hematopoietic system

decreased T cell proliferation ( J:130882 )

• CD4 T cells proliferate in vitro at normal levels when stimulated with anti-CD3 antibody compared

increased memory T cell number ( J:130882 )

• increased number of CD44^highCD62^low T cells in the spleen and lymph nodes

increased activated T cell number ( J:130882 )

• increased number of CD69⁺ T cells are found in the spleen and lymph nodes

cellular

decreased T cell proliferation ( J:130882 )

• CD4 T cells proliferate in vitro at normal levels when stimulated with anti-CD3 antibody compared