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Phenotypes Associated with This Genotype
Genotype
MGI:3773279
Allelic
Composition		 Tg(Cd4-cre)1Cwi/?
Tg(TcraTcrb)425Cbn/?
Traf6tm2Ywc/Traf6tm2Ywc
Genetic
Background		 involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Cd4-cre)1Cwi mutation (12 available)
Tg(TcraTcrb)425Cbn mutation (6 available)
Traf6tm2Ywc mutation (0 available); any Traf6 mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased interleukin-2 secretion ( J:130882 )
• CD4 T cells from mice immunized with OVA antigen secrete almost 10-fold more IL-2 upon in vitro antigen restimulate compared to mice transgenic only for the T cell receptor
abnormal lymphocyte anergy ( J:130882 )
• OVA antigen specific T cells continue to proliferate upon antigen restimulation in a transfer model of tolerance

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory