Phenotypes Associated with This Genotype

Genotype
MGI:3773278

• Allelic Composition: Traf6^tm2Ywc/Traf6^tm2Ywc; Tg(Cd4-cre)1Cwi/?
• Genetic Background: involves: C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased memory T cell number ( J:130882 )

• increased number of CD44^highCD62^low T cells are found in the spleen and lymph nodes

increased activated T cell number ( J:130882 )

• increased number of CD69⁺ T cells are found in the spleen and lymph nodes

abnormal lymphocyte anergy ( J:130882 )

• CD4 T cells are resistant to anergy induced in vitro as measured by cellular proliferation in response to anti-CD3 restimulation

• proliferation rates are 5-10 fold higher upon restimulation compared to wild-type controls

• CD4 T cells expressing the Vbeta8 chain continue to proliferate upon restimulation with the superantigen SEB compared to CD4 T cells from control mice that are tolerized and do not proliferate in response to restimulation

hematopoietic system

increased memory T cell number ( J:130882 )

• increased number of CD44^highCD62^low T cells are found in the spleen and lymph nodes

increased activated T cell number ( J:130882 )

• increased number of CD69⁺ T cells are found in the spleen and lymph nodes