Phenotypes Associated with This Genotype

Genotype
MGI:3773268

• Allelic Composition: Ascl2^tm1Alj/Ascl2⁺
• Genetic Background: involves: 129 * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:23260 )

• maternal inheritance of the mutant allele leads to embryonic death due to placental failure

• mice whom paternally inherit the mutant allele are viable

embryo

abnormal chorion morphology ( J:23260 )

• chorion membrane is underdeveloped in embryos whom maternally inherit the mutant allele

abnormal spongiotrophoblast layer morphology ( J:23260 )

• spongiotrophoblast fails to develop in embryos whom maternally inherit the mutant allele

cellular

paternal imprinting ( J:23260 )

• the paternal allele is functionally inactivated

• mice whom maternally inherit the mutant allele are functionally null homozygotes and die during embryogenesis

• mice whom paternally inherit the mutant allele are viable