Phenotypes Associated with This Genotype

Genotype
MGI:3773153

• Allelic Composition: Atrn^{Gt(PST112)Byg}/Atrn^{Gt(PST112)Byg}; Tg(ACTB-Atrnl1)B4Tmg/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

brain vacuoles ( J:130463 )

• brain vacuolation is rescued with only sparse, scattered vacuoles observed at 3 months

• mild to moderate vacuolation occurs at 6 months

• Background Sensitivity: rescue of vacuolation occurs on both a C3H/HeJ and C57BL/6J background

abnormal myelination ( J:130463 )

• hypomyelination observed in homozygotes is partially rescued

integument

integument phenotype ( J:130463 )

N • unlike homozygotes, mice display a wild-type coat color