Phenotypes Associated with This Genotype

Genotype
MGI:3773057

• Allelic Composition: Trp63^tm2Brd/Trp63^tm2Brd
• Genetic Background: involves: 129S7/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

limbs/digits/tail

abnormal limb morphology ( J:100483 )

• at E17.5

abnormal apical ectodermal ridge morphology ( J:135784 )

• unstratified

cellular

decreased cell proliferation ( J:100483 )

early cellular replicative senescence ( J:100483 )

• mice exhibit an increase in cellular senescence

craniofacial

abnormal craniofacial morphology ( J:100483 )

• at E17.5

muscle

muscle phenotype ( J:98439 )

N • proximal thigh and cloacal/perineal muscles are fully formed

embryo

abnormal apical ectodermal ridge morphology ( J:135784 )

• unstratified

integument

abnormal skin morphology ( J:100483 )

• at E17.5

abnormal epidermal layer morphology ( J:100483 )

• mice exhibit stratified epidermal layer and arrested epidermal morphogenesis