Phenotypes Associated with This Genotype

Genotype
MGI:3773053

• Allelic Composition: Kit^tm1Shta/Kit⁺
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

abnormal digestive system morphology ( J:130890 )

• mice exhibit spindle-shaped cell proliferations in the lower esophagus, stomach, proximal duodenum and colon unlike in wild-type mice

• however, small intestines are normal

abnormal esophagus morphology ( J:130890 )

• mice exhibit black lesions at the lower esophagus due to melanocyte aggregations in muscularis propria and adventitia

increased gastrointestinal stromal tumor incidence ( J:130890 )

• mice exhibit a small but apparent whitish, linear tumor in the cecum

• mice develop cecal tumors at any age

neoplasm

increased gastrointestinal stromal tumor incidence ( J:130890 )

• mice exhibit a small but apparent whitish, linear tumor in the cecum

• mice develop cecal tumors at any age

reproductive system

reproductive system phenotype ( J:130890 )

N • unlike with mice carrying other alleles of this gene, mice exhibit normal spermatogenesis