Phenotypes Associated with This Genotype

Genotype
MGI:3773015

• Allelic Composition: Sox4^tm1.1Vlf/Sox4^tm1.1Vlf
• Genetic Background: involves: 129 * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:130461 )

• mice die between E13.5 and E14.5 likely due to regurgitation of blood into the heart

cardiovascular system

persistent truncus arteriosus ( J:130461 )

abnormal semilunar valve development ( J:130461 )

• endocardial cushions form at the level of the semilunar valve but functional flaps do not form

abnormal interventricular septum morphology ( J:130461 )

• at E13.5, mice exhibit incomplete septation of the ventricles

homeostasis/metabolism

edema ( J:130461 )

• at E13.5