Phenotypes Associated with This Genotype

Genotype
MGI:3772944

• Allelic Composition: Adm^tm1Unc/Adm^tm1Unc
• Genetic Background: 129S6/SvEvTac-Adm^tm1Unc

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Generalized edema in Calcrl^tm1Kmca/Calcrl^tm1Kmca, Adm^tm1Unc/Adm^tm1Unc, and Ramp2^tm1Kmca/Ramp2^tm1Kmca mice

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:130930 )

• mice die 1 to 2 days after developing edema

immune system

abnormal lymph organ development ( J:130930 )

• at E13.5, the jugular lymph sac is smaller than in wild-type mice despite lymphedema

• proliferation of lymphatic endothelial cells is decreased compared to in wild-type mice

homeostasis/metabolism

edema ( J:130930 )

• at E13.5, mice exhibit interstitial edema without hemorrhage

lymphedema ( J:130930 )