Phenotypes Associated with This Genotype

Genotype
MGI:3772934

• Allelic Composition: Del(7Ins2-Tel)1Lef/+
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:130399 )

• embryos inheriting the chromosome deletion from their mothers die around E10.5

• females inheriting the chromosome deletion paternally are viable and fertile

embryo

abnormal trophoblast layer morphology ( J:130399 )

• embryos whom maternally inherit the chromosome deletion have a thicker giant cell layer in their placenta

absent spongiotrophoblast layer ( J:130399 )

• embryos whom maternally inherit the chromosome deletion lack spongiotrophoblasts in their placenta

pale yolk sac ( J:130399 )

• there is an absence of blood in the yolk sacs of embryos whom maternally inherit the chromosome deletion

cardiovascular system

pericardial effusion ( J:130399 )

• is observed in E10.5 embryos whom maternally inherit the chromosome deletion

cellular

paternal imprinting ( J:130399 )

• the chromosome deletion contains paternally silenced genes so that no abnormal phenotype is observed when the deletion is inherited paternally and embryonic lethality is observed when the deletion is inherited maternally

homeostasis/metabolism

pericardial effusion ( J:130399 )

• is observed in E10.5 embryos whom maternally inherit the chromosome deletion