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Phenotypes Associated with This Genotype
Genotype
MGI:3772816
Allelic
Composition
Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sortm1(HBEGF)Awai
Tg(Cd4-cre)1Cwi/0
Genetic
Background
involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(HBEGF)Awai mutation (4 available); any Gt(ROSA)26Sor mutation (935 available)
Tg(Cd4-cre)1Cwi mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• following 3 days of diptheria toxin injection, splenic T to B lymphocyte ratio is reduced from a mean of 0.5 in controls to 0.1 in double mutant animals
• numbers of CD4+ and CD8+ T lymphocytes are ~equally decreased

hematopoietic system
• following 3 days of diptheria toxin injection, splenic T to B lymphocyte ratio is reduced from a mean of 0.5 in controls to 0.1 in double mutant animals
• numbers of CD4+ and CD8+ T lymphocytes are ~equally decreased


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory