Analysis Tools
growth/size/body
weight loss
(
J:131076
)
|
• after intaperitoneal injection with diptheria toxin 3 times daily for 7 days, mice present with weight loss after ~30 days
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behavior/neurological
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• after intaperitoneal injection with diptheria toxin 3 times daily for 7 days, mice present with tremor after ~30 days
|
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• after intaperitoneal injection with diptheria toxin 3 times daily for 7 days, mice present with hindlimb paralysis after ~30 days
|
nervous system
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• 3 days following diptheria toxin injection 3 times daily for 7 days, substantial apoptosis is detected in the granular layer of the cerebella of double mutants; cells are likely oligodendrocytes, but may be granule cells
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astrocytosis
(
J:131076
)
|
• reactive astrogliosis is observed, as well as inflammatory cells, in oligodendrocytes after diptheria toxin injection 3 times daily for 7 days
|
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• after intaperitoneal injection with diptheria toxin 3 times daily for 7 days, severe destruction of myelinated structures throughout the CNS is observed
|
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• diptheria toxin-induced demyelination is observed in treated double mutants
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immune system
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• after diptheria toxin treatment for 7 days, low titers of IgM diptheria toxin-specific antibodies are detected in the serum; DT-specific IgG1 antibodies are detected later, and amounts are ~50-fold lower than in a typical hapten-induced antiboby response
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cellular
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• 3 days following diptheria toxin injection 3 times daily for 7 days, substantial apoptosis is detected in the granular layer of the cerebella of double mutants; cells are likely oligodendrocytes, but may be granule cells
|
