Phenotypes Associated with This Genotype

Genotype
MGI:3772779

• Allelic Composition: Nampt^{Gt(RRT307)Byg}/Nampt⁺
• Genetic Background: B6.129P2-Nampt^{Gt(RRT307)Byg}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased insulin secretion ( J:130534 )

• female mice exhibit decreased insulin secretion 15 and 30 minutes after glucose injection unlike wild-type mice

• islet cells from female mice cultured in RPM1 media and 1 uM nicotinamide exhibit decreased insulin secretion in culture when stimulated with glucose compared to wild-type mice

• however, decreased insulin secretion is reversed following administration of nicotinamide mononucleotide

decreased circulating glucose level ( J:130534 )

• fasted male mice exhibit decreased glucose levels compared to wild-type mice

impaired glucose tolerance ( J:130534 )

• female mice exhibit impaired glucose tolerance compared to male mice and wild-type mice

• however, impaired glucose tolerance is reversed following administration of nicotinamind mononucleotide

endocrine/exocrine glands

decreased insulin secretion ( J:130534 )

• female mice exhibit decreased insulin secretion 15 and 30 minutes after glucose injection unlike wild-type mice

• islet cells from female mice cultured in RPM1 media and 1 uM nicotinamide exhibit decreased insulin secretion in culture when stimulated with glucose compared to wild-type mice

• however, decreased insulin secretion is reversed following administration of nicotinamide mononucleotide