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Phenotypes Associated with This Genotype
Genotype
MGI:3772773
Allelic
Composition		 Nfe2l2tm1Mym/Nfe2l2tm1Mym
Tg(Alb1-cre)1Dlr/0
n-TUtca2tm2Mym/n-TUtca2tm2.1Mym
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * DBA/2 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfe2l2tm1Mym mutation (5 available); any Nfe2l2 mutation (94 available)
n-TUtca2tm2.1Mym mutation (1 available); any n-TUtca2 mutation (3 available)
n-TUtca2tm2Mym mutation (0 available); any n-TUtca2 mutation (3 available)
Tg(Alb1-cre)1Dlr mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
lethality at weaning, incomplete penetrance ( J:130723 )
• the highest mortality rates occur at 3 weeks of age
premature death ( J:130723 )
• all mice die by 7 weeks with the highest mortality rates at 3 weeks of age

liver/biliary system
increased hepatocyte apoptosis ( J:130723 )
• at 3 weeks of age, mice exhibit hepatocyte apoptosis not observed in either single mutants or wild-type mice
abnormal hepatocyte morphology ( J:130723 )
• at 3 weeks of age, mice exhibit hepatocyte necrosis not observed in either single mutants or wild-type mice
liver degeneration ( J:130723 )
• at 3 weeks of age, mice exhibit liver degeneration not observed in either single mutants or wild-type mice

homeostasis/metabolism

cellular
increased hepatocyte apoptosis ( J:130723 )
• at 3 weeks of age, mice exhibit hepatocyte apoptosis not observed in either single mutants or wild-type mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/20/2026
MGI 6.24 		The Jackson Laboratory