Phenotypes Associated with This Genotype

Genotype
MGI:3772456

• Allelic Composition: Tg(CAG-SAC/EGFP)35Rang/0
• Genetic Background: involves: C3H * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:125633 )

N • mice display normal lifespan compared to wild-type mice

neoplasm

decreased tumor incidence ( J:125633 )

• transgenic mice do not develop spontaneous liver tumors or splenic lymphomas in contrast to wild-type controls

• no mice develop prostatic neoplasms

decreased liver tumor incidence ( J:125633 )

• mice do not develop spontaneous hepatocarcinomas or lymphomas in contrast to control wild-type B6C3 hybrid mice and mice expressing only a GFP transgene which develop such liver tumors by ~18 months of age

decreased lymphoma incidence ( J:125633 )

• transgenic mice do not develop spontaneous splenic lymphomas, in contrast to wild-type controls

liver/biliary system

liver/biliary system phenotype ( J:125633 )

N • liver architecture is normal in mice resistant to tumor development

decreased liver tumor incidence ( J:125633 )

• mice do not develop spontaneous hepatocarcinomas or lymphomas in contrast to control wild-type B6C3 hybrid mice and mice expressing only a GFP transgene which develop such liver tumors by ~18 months of age

hematopoietic system

hematopoietic system phenotype ( J:125633 )

N • spleen morphology and architecture is normal in mice

reproductive system

reproductive system phenotype ( J:125633 )

N • transgenic mice have normal-sized litters and both sexes display normal level of fertility

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:125633 )

N • prostate glands are normal