Phenotypes Associated with This Genotype

Genotype
MGI:3771959

• Allelic Composition: Fjx1^tm1Awp/Fjx1^tm1Awp; Tg(Thy1-YFP)HJrs/0
• Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal dendrite morphology ( J:130206 )

• dendritic trees of pyramidal cells in the CA1 region of the hippocampus are less complex than in wild-type mice

• the length of dendrites formed by granule cells in the dentate gyrus is increased (197+/-7 um compared to 164+/-7 um in wild-type mice)

• the complexity of apical dendrites in CA1 is reduced

• however, the complexity of granule cell dendrites in the dentate gyrus and the length of apical dendrites are normal

• in culture, dendrites of hippocampal neurons are 56% longer at day 3 and 88% longer at day 7 compared to wild-type neurons and the number of dendrites per cell is increased (1.8+/-0.2 compared to 1.2+/-0.1 for wild-type neurons) without affecting axon length, the number of axons per cell or the number of dendrites per cell