Phenotypes Associated with This Genotype

Genotype
MGI:3771850

• Allelic Composition: Prkar1a^tm1.2Lsk/Prkar1a^tm1.2Lsk; Tg(Ghrhr-cre)3242Lsk/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased pituitary gland tumor incidence ( J:130264 )

• when pituitary glands are examined, mice exhibit an increased rate of tumorigenesis (in 48% of mice compared to 30.6% of wild-type mice)

• however, the number of prolactinomas is not increased relative to in wild-type mice

• nonprolactonmas stain positive for multiple hormone subtypes including Prl, GH and TSH

homeostasis/metabolism

increased circulating growth hormone level ( J:130264 )

• regardless of tumor status mice exhibit increased serum growth hormone levels (28.27+/-41.4 ng/ml compared to 8.44+/-20.7 ng/ml in wild-type mice)

endocrine/exocrine glands

increased pituitary gland tumor incidence ( J:130264 )

• when pituitary glands are examined, mice exhibit an increased rate of tumorigenesis (in 48% of mice compared to 30.6% of wild-type mice)

• however, the number of prolactinomas is not increased relative to in wild-type mice

• nonprolactonmas stain positive for multiple hormone subtypes including Prl, GH and TSH

nervous system

increased pituitary gland tumor incidence ( J:130264 )

• when pituitary glands are examined, mice exhibit an increased rate of tumorigenesis (in 48% of mice compared to 30.6% of wild-type mice)

• however, the number of prolactinomas is not increased relative to in wild-type mice

• nonprolactonmas stain positive for multiple hormone subtypes including Prl, GH and TSH