Phenotypes Associated with This Genotype

Genotype
MGI:3771618

• Allelic Composition: Arid5b^tm1Whit/Arid5b⁺
• Genetic Background: involves: 129S1/Sv * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, incomplete penetrance ( J:130390 )

• Background Sensitivity: only 68.2% of expected mice survive birth in the first generation while survival is 66.1% on a pure 129S1 background, 68.8% after one cross to C57BL/6J and 81.5% after additional crosses to C57BL/6J

adipose tissue

decreased white adipose tissue amount ( J:130390 )

• when fed a high fat diet, white adipose tissue is 28.3+/-6.4 compared to 51.0+/-4.1 for wild-type mice for males and 18.6+/-1.8compared to 36.3+/-7.2 for wild-type mice for female mice

decreased percent body fat/body weight ( J:130390 )

• when fed a high fat diet, percent fat is 18.5+/-6.5% compared to 42.1.6% for wild-type mice for males and 16.7+/-3.7% compared to 31.9+/-2.8% for wild-type mice for female mice

behavior/neurological

decreased food intake ( J:130390 )

♀ • female mice consume 0.45+/-0.02 kcal per mouse per day compared to 0.52+/-0.07 kcal per mouse per day for wild-type females on a high-fat diet

increased food intake ( J:130390 )

♂ • male mice consume 0.45+/-0.02 kcal per mouse per day compared to 0.39+/-0.02 kcal per mouse per day for wild-type males on a standard diet while on a high fat diet male mice consume 0.43+/-0.02 kcal per mouse per day compared to 0.35+/-0.01 kcal per mouse per day for wild-type males on a standard diet

growth/size/body

decreased susceptibility to diet-induced obesity ( J:130390 )

homeostasis/metabolism

decreased susceptibility to diet-induced obesity ( J:130390 )