Analysis Tools
mortality/aging
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• Background Sensitivity: only 6.4% of mice survive after birth on a 129S1 background compared to 38% on a mixed 129S1 and C57BL/6J background
• however, mice that survive appear healthy
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adipose tissue
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• fat lobule diameter is decreased while cell density is increased compared to in wild-type mice in intrascapular brown adipose tissue and in inguinal and ovarian white adipose tissue depots
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• when fed a high fat diet, white adipose tissue is 13.5+/-3.1 compared to 51.0+/-4.1 for wild-type mice for males and 8.2+/-3.0 compared to 36.3+/-7.2 for wild-type mice for female mice
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• unlike in wild-type mice, lipid vacuoles in brown adipose tissue are absent in neoneates
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• when fed a high fat diet, when fed a high fat diet percent fat is 23.7+/-3.4% compared to 42.1.6% for wild-type mice for males and 10.6+/-3.1% compared to 31.9+/-2.8% for wild-type mice for female mice
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behavior/neurological
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• male mice consume 0.48+/-0.02 kcal per mouse per day compared to 0.39+/-0.02 kcal per mouse per day for wild-type males on a standard diet while on a high fat diet male mice consume 0.48+/-0.02 kcal per mouse per day compared to 0.35+/-0.01 kcal per mouse per day for wild-type males
• female mice consume 0.53+/-0.02 kcal per mouse per day compared to 0.45+/-0.02 kcal per mouse per day for heterozygote females on a standard diet while on a high fat diet female mice consume 0.51+/-0.01 kcal per mouse per day compared to 0.43+/-0.02 kcal per mouse per day for wild-type females
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growth/size/body
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• although a normal weight at birth, mice exhibit decreased weight compared to wild-type mice by day 5
• however, prenatal weight is normal
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• mice are shorter than wild-type mice at early ages but achieve 90% of wild-type weight by 17 weeks of age
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homeostasis/metabolism
