About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3771614
Allelic
Composition		 Cfbtm1Hrc/Cfbtm1Hrc
Genetic
Background		 involves: 129S/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cfbtm1Hrc mutation (1 available); any Cfb mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
impaired complement classical pathway ( J:130108 )
• antibody-mediated complement of sera is severely impaired as measured by C3 activation in the presence of OVA and anti-OVA immunoglobulins
decreased susceptibility to Coronaviridae infection ( J:286325 )
• mice show some protection from intranasal infection with the mouse-adapted SARS-CoV MA15 , showing less weight loss than in wild-type controls, but more weight loss than in C3tm1Crr homozygotes

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory