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Phenotypes Associated with This Genotype
Genotype
MGI:3771614
Allelic
Composition
Cfbtm1Hrc/Cfbtm1Hrc
Genetic
Background
involves: 129S/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cfbtm1Hrc mutation (1 available); any Cfb mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• antibody-mediated complement of sera is severely impaired as measured by C3 activation in the presence of OVA and anti-OVA immunoglobulins
• mice show some protection from intranasal infection with the mouse-adapted SARS-CoV MA15 , showing less weight loss than in wild-type controls, but more weight loss than in C3tm1Crr homozygotes


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/07/2021
MGI 6.17
The Jackson Laboratory