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Phenotypes Associated with This Genotype
Genotype
MGI:3771572
Allelic
Composition
Txktm1Pls/Txktm1Pls
Genetic
Background
involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Txktm1Pls mutation (0 available); any Txk mutation (39 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• splenocytes stimulated with anti-CD3e or concanavalin A secrete ~50% of levels of Il-2 produced by wild-type cells
• mice infected with Toxoplasma gondii survive the early infection which requires natural killer cells; compared to Itk-null and double-null mice, ~50% of animals die by 102 days, while >80% of wild-type mice survive over 18 weeks


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/18/2025
MGI 6.24
The Jackson Laboratory