Phenotypes Associated with This Genotype

Genotype
MGI:3771571

• Allelic Composition: Inhba^tm1Zuk/Inhba^tm1Zuk
• Genetic Background: involves: 129S7/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Cellular defects in the epididymides of the Inhba^tm1Zuk/Inhba^tm1Zuk mouse

reproductive system

abnormal epididymis morphology ( J:122819 )

♂ • epididymis fails to develop the characteristic coiling in the epithelium

♂ • however, testosterone production and action is normal

abnormal epididymis epithelium morphology ( J:122819 )

♂ • the typical increase in proliferation of cells in the Wolffian duct epithelium as it transforms into the epididymis from E15.5 to E19.5 is absent in mutants

embryo

abnormal Wolffian duct morphology ( J:122819 )

• Wolffian duct fails to elongate and coil, leaving a straight duct in the mesonephros

• the epithelial layer of the Wolffian duct becomes high columnar in shape compared to high cuboidal to low columnar in wild-type, and cell width decreases as the epithelial layer becomes crowded

• mesenchymal cells surrounding the duct are condensed and disorganized