Phenotypes Associated with This Genotype

Genotype
MGI:3771567

• Allelic Composition: Nat2^tm1Esim/Nat2⁺
• Genetic Background: A.129P2-Nat2^tm1Esim

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Overview of ocular phenotype of Nat2^tm1Esim/Nat2⁺ mice

vision/eye

abnormal eye morphology ( J:121985 )

• ocular defects are observed in 5.5% of A/J offspring derived by backcrossing of wild-type mice to heterozygous mutants

aphakia ( J:121985 )

• mutants with microphthalmia exhibit complete absence of the lens tissue

cataract ( J:121985 )

• cataract analysis shows a failure of the lens to separate from the cornea, plaques within the lens tissue, and disorganized lens tissue in the anterior subcapsular region

microphthalmia ( J:121985 )

• microphthalmic eyes show complete absence of lens tissue with an intact cornea but globe filled with folded retina

anophthalmia ( J:121985 )

• most severe cares show no evidence of an eye