Mouse Genome Informatics
phenotype observed in females
phenotype observed in males
N normal phenotype
• all homozygous mice died by 11-13 months of age
• direct cause of death could not determined

• less severe clasping of limbs in old (9-12 months) mice when lifted by the tail showing only partial retraction and still spreading toes
• most homozygous mice showed moderate to severe decline in ambulation in the home cage by age 9-10 months
• only some of oldest mice revealed a motor deficit on beam walk test
• paralysis progressed to include the forelimbs with age in all animal by age 9-10 months
• minor paresis of the hind limbs in some mice at 6 months
• no motor problems before age 6 months

• due to muscle and tissue wasting by 9-10 months

nervous system
• axonal dilations were completely absent in brain and spinal cord at any age
• neurofibrillary pathology was evident in all old mice by silver impregnation and fluorescent staining with thioflavin S and X-34
• positive tauopathy was observed in brain and spinal cord neurons
• fraction of neuronal tau in aging mice was hyper phosphorylated concomitant with conformational changes and aggregation co-localizing in the same neurons

Mouse Models of Human Disease
Alzheimer Disease; AD 104300 J:96869