Phenotypes Associated with This Genotype

Genotype
MGI:3771316

• Allelic Composition: Tg(Thy1-MAPT)1Vln/0
• Genetic Background: FVB/N-Tg(Thy1-MAPT)1Vln

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

limb grasping ( J:96869 )

• severe clasping of limbs when lifted by the tail

abnormal motor coordination/balance ( J:96869 )

• severe motor defect by 6-8 weeks

• no mouse was able to stay on the bean even at 3 moths of age

nervous system

abnormal axon morphology ( J:96869 )

• progressive axonopathy with numerous axonal dilations in brain and spinal cord

• reaction with thioflavin S or X-34 was completely absent confirming the total absence of tauopathy

axon degeneration ( J:96869 )

• Wallerian degeneration following axonopathy

muscle

muscular atrophy ( J:96869 )

• muscle wasting following axonopathy