Phenotypes Associated with This Genotype

Genotype
MGI:3771307

• Allelic Composition: Rps6kb1^tm1Gtho/Rps6kb1^tm1Gtho
• Genetic Background: B6.129P2-Rps6kb1^tm1Gtho

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Beta cell and islet size in Tg(Ins2-Akt1*)3Mbb/0, Rps6kb1^tm1Gtho/Rps6kb1^tm1Gtho, and double mutant mice

endocrine/exocrine glands

abnormal pancreatic beta cell morphology ( J:144599 )

• pancreatic beta cells are 30% smaller than in wild-type pancreas

decreased pancreatic beta cell mass ( J:144599 )

• beta cell mass is reduced by half

abnormal pancreatic beta cell physiology ( J:144599 )

• beta cell size is not reduced by rapamycin or nutrient starvation as seen in wild-type cells

growth/size/body

decreased body weight ( J:144599 )

postnatal growth retardation ( J:89696 )

• growth retardation is comparable to that observed on a mixed background

homeostasis/metabolism

decreased circulating insulin level ( J:144599 )

• 35% reduction of plasma insulin levels

increased insulin sensitivity ( J:144599 )