Phenotypes Associated with This Genotype

Genotype
MGI:3771180

• Allelic Composition: Dap3^{Gt(OST147863)Lex}/Dap3^{Gt(OST147863)Lex}
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:129756 )

• embryos fail to progress beyond E9.5

cellular

abnormal mitochondrial morphology ( J:129756 )

• average size is 2-fold smaller than in wild-type controls

• some mitochondria have swollen cristae

• other mitochondria appear to be remnants with a collapsed appearance

• only 20% of mitochondria in the cardiac muscle have a normal morphology

decreased fibroblast apoptosis ( J:129756 )

• mouse embryonic fibroblasts are resistant to apoptosis initiated by stimulation of TNF receptors

embryo

failure of initiation of embryo turning ( J:129756 )

• embryos lack axial turning

decreased embryo size ( J:129756 )

• embryos are markedly reduced in size at E9.5

abnormal placenta size ( J:129756 )

• the placenta is smaller than wild-type controls

abnormal placenta development ( J:129756 )

• in some cases the placenta deteriorates during development

growth/size/body

decreased embryo size ( J:129756 )

• embryos are markedly reduced in size at E9.5

hematopoietic system

anemia ( J:129756 )

• all E9.5 embryos appear highly anemic