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Phenotypes Associated with This Genotype
Genotype
MGI:3771145
Allelic
Composition		 Nbntm2.1Jpt/Nbn+
Rad50tm2Jpt/Rad50tm2Jpt
Genetic
Background		 involves: 129S7/SvEvBrd * 129/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nbntm2.1Jpt mutation (0 available); any Nbn mutation (59 available)
Rad50tm2Jpt mutation (0 available); any Rad50 mutation (53 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:129762 )
N
• unlike Rad50tm2Jpt homozygotes, mice do not exhibit increased lethality or anemia at 8 months

cellular
decreased apoptosis ( J:129762 )
• attrition of B-, T- and myeloid cell lineages, gut and seminiferous tubules observed in Rad50tm2Jpt homozygotes is mitigated

hematopoietic system
anemia ( J:129762 )
• compared to Rad50tm2Jpt homozygotes, the age of onset of anemia is reduced

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory