Analysis Tools
cellular
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• following exposure to 10 Gy, mouse embryonic fibroblast cells exhibit a defect in the intra-S phase checkpoint and only 36% of cells suppress DNA synthesis compared to 51% of wild-type cells
• exposure to ionizing radiation results in a reduction of the apoptotic response in thymus cells compared to wild-type
mice exhibit increased apoptosis in the thymus following exposure to ionizing radiation
• however, the distribution of thymocytes is normal
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